Promoting effects of phenobarbital and 3′-methyl-4-dimethylaminoazobenzene on the appearance of γ-glutamyltranspeptidase positive foci in rat liver pretreated …
T Shirai, K Hosoda, K Hirose, M Hirose, N Ito - Cancer letters, 1985 - Elsevier
The promotion potential of phenobarbital (PB) and 3′-methyl-4-dimethylaminoazobenzene
(3′-Me-DAB) on liver carcinogenesis after initiation with various doses of
diethylnitrosamine (DEN) was assessed using an in vivo short term system. Male F344 rats
were pretreated with a single intraperitoneal injection of varing doses of DEN (0, 6, 12, 25,
50, 100 or 200 mg/kg body wt), and 2 weeks later were treated with 0.05% PB or 0.06% 3′-
Me-DAB for 6 weeks. All animals were subjected to partial hepatectomy 3 weeks after the …
(3′-Me-DAB) on liver carcinogenesis after initiation with various doses of
diethylnitrosamine (DEN) was assessed using an in vivo short term system. Male F344 rats
were pretreated with a single intraperitoneal injection of varing doses of DEN (0, 6, 12, 25,
50, 100 or 200 mg/kg body wt), and 2 weeks later were treated with 0.05% PB or 0.06% 3′-
Me-DAB for 6 weeks. All animals were subjected to partial hepatectomy 3 weeks after the …
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